People at the AI Lab
Alumni and Guests
 |
| Artificial Intelligence Laboratory
Department of Informatics University of Zurich Andreasstrasse 15 (Office 2.14) 8050 Zurich Switzerland phone: + 41 44 635 45 91 fax: + 41 44 635 45 07 mobile: + 41 79 232 74 36 e-mail: fuchslin@ifi.uzh.ch |
Research
| My main research is in the field of physical and
biological self-assembly and its connection to information technology
and evolution. Self-assembly enables the construction of long range order from local interactions. By exploiting emerging patterns, logical aspects of a problem can be transferred into geometrical ones. As an example, in case of digital circuitry, we showed that self-assembly enables the evolution of scalable devices (such as multipliers) by induction from a limited set of test problems. An important aspect of biological self-assembly is the softness of the individual components. Presently, we are studying the advantages and limitations of self-assembling multivesicualr systems, in theory as well as in experiment. |
Publications
Paper
Publications, Patents, Posters, TalksPaperPublished: R. M. Füchslin, T. Maeke, U. Tangen, and J. S. McCaskill. Evolving inductive generalization via genetic self-assembly. Adv. in Compl. Systems 9: 1-29 (2006). Weiss M, Gerber S, Füchslin RM, et al. “Accurate continuous drug delivery at low infusion rate with a novel microvolumetric infusion pump (MVIP): pump design, evaluation and comparison to the current standard”, Anaesthesia 59 (11): 1133-1137 (2004). Füchslin R.M., Altmeyer S., McCaskill J.S., “Evolutionary stabilization of generous replicases by complex formation”, Europ. Phys J. B 38 (1): 103-110 (2004). Altmeyer S., Füchslin R.M., McCaskill J.S., “Folding stabilizes the evolution of catalysts”, Artificial Life 10 (1): 23-38 (2004). Füchslin R.M., Meier P.F., „A method for the study of spatially non-homogeneous quasiparticle and phonon distributions”, Nucl. Instr. and Methods A 485 522-532 (2002). Neff T.A., Fellmann C, Füchslin R.M., et al. “The Panomat (R) P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates”, Canad. J. of Anaesthesia, 49 (10): 1048-1052 DEC 2002. McCaskill J. S., Füchslin R. M., Altmeyer S, “The stochastic evolution of catalysts in spatially resolved molecular systems'', Biol. Chem. 382 (9): 1343-1363 (2001). Füchslin R. M., McCaskill J. S., “Evolutionary self-organization of cell-free genetic coding'', Proc. Natl. Acad. Sci. USA 98 (16): 9185-9190 (2001), communicatd by Manfred Eigen. Füchslin R. M. , Shen Y, Meier P. F., “An efficient algorithm to determine fractal dimensions of point sets'', Phys. Lett. A 285 (1-2): 69-75 (2001) Nussbaumer T., Lerch P., Kirk E., et al., “Quasiparticle diffusion in tantalum using superconducting tunnel junctions'', Phys. Rev. B 61 (14): 9719-9728 (2000). R. M. Füchslin, ``Time Evolution fo Quasiparticle and Phonon Distribution in Superconducting Films'', Inaugural-Dissertation Univ. Zürich (1998). Cox S.F.J., Füchslin R. M., Meier P. F. , et al., “Muon level crossing resonance in niobium'', Hyperfine Interact. 106 (1-4): 57-62 (1997). Schafroth S., Füchslin R. M., Meier P. F., “Time evolution of nonequilibrium quasiparticle and phonon distributions in superconducting films'', Nucl. Instrum. Meth. A 370 (1): 69-71 (1996). Füchslin R. M., Meier P. F., “Level-Crossing Resonance-Spectra for Bond-Centered Muonium in Silicon'' , Philos. Mag. B 72 (2): 201-208 (1995).
Füchslin
R. M., Meier P. F. “Calculation of Muon Level-Crossing
Resonance-Spectra for Si-B and Si-Al'' Hyperfine Interact. 86 (1-4):
741-746 (1994).
Rudolf M. Füchslin, Anders Eriksson, Harold Fellermann and Hans-Joachim Ziock, “Coarse-Graining and Scaling in Dissipative Particle Dynamics”, submitted to J. Chem. Phys. Rudolf M. Füchslin, Thomas Maeke, & John S. McCaskill, “Multipolar Reactive DPD: A Novel Tool for Spatially Resolved Simulations in Cell Biology”, submitted. T. Maeke, R. M. Füchslin, and J. S. McCaskill, "Reactive Dissipative Particle Dynamics for self-organized compartmental systems: Applications", in preparation. R. M. Füchslin, T. Maeke, and J. S. McCaskill, "Molecular Sorting: theoretical tools beyond compartment models", in preparation. Tangen, U., Füchslin, R.M., Maeke, T., and McCaskill, J. S.. “Progress in Digital Evolution: Largest 4-bit Multiplier Evolving Using Reconfigurable Hardware.”, Submitted.
PosterNadine Mennes, Thomas Maeke, Rudolf M. Füchslin, Uwe Tangen and John S. McCaskill, “Simulations of the vesicular transport in the endocytic pathway with mprDPD”, Status Seminar HepatoSys, 14-16. 10. 2007 Heidelberg, Germany. Rudolf M. Füchslin, Thomas Maeke, John S. McCaskill, “Multipolar Reactive Dissipative Particle Dynamics for Systems Biology: Reaction Controlled Membrane Morphology as Bases for Modelling Endocytosis in Space and Time”, Systems Biology of Mammalian Cells SBMC 06, 12. – 14. 7. 2006, Heidelberg, Germany. Rudolf M. Füchslin, Thomas Maeke, Sagar Poudel, Uwe Tangen, John S. McCaskill, “Multipolar Reactive Dissipative Particle Dynamics for Systems Biology: Systems Endocytosis Modeling requires a spatially resolved Supramolecular Chemical Kinetics platform”, Status Seminar HepatoSys, 29.-30. 11. 2005 Berlin, Germany. Rudolf M. Füchslin, Thomas Maeke, Uwe Tangen, John S. McCaskill, “Genetic Self-Assembly: a novel route to complex design”, poster at ECCS 05 November 13-18, 2005. Paris, France. Thomas Maeke, Rudolf M. Füchslin, Uwe Tangen, John S. McCaskill. “Reactive DPD multiscale simulations (preserving the hydrodynamic limit) for artificial cells with microfluidic support., poster “Evolution, Information and Computation: From Living to Non-Living Matter”, PACE Workshop, European Center for Living Technology, Venice, Italy, 23rd - 26th May 2005 U. Tangen, R. Füchslin, T. Maeke, P. Wagler, and J. S. McCaskill. Closing the loop: wet in silico bioprocessing. In E. Neumann, editor, Biophysical Chemistry, Molecular Biology and Cybernetics of Cell Functions 39th Winter Seminar. 2004. poster. R. M. Füchslin, S. Altmeyer, J. S. McCaskill, “Evolvable Universal Construction'', 37th Winter Seminar Winterseminar of Manfred Eigen, Klosters, January 2002. R. M. Füchslin, S. Altmeyer, J. S. McCaskill, “Evolvable Universal Construction and the GRT-model'', 2nd caesarium “Coupling of Biological and Electronic Systems'', Bonn Nov. 2000. R. M. Füchslin, S. Schafroth, P. F. Meier, “Large Scale Time Evolution of Quasiparticle and Phonon Distributions in Superconducting Films'', Swiss Workshop on Superconductivity, Les Diablerets, CH, 1997.
S. Schafroth, R. M. Füchslin, and P. F. Meier, “Time evolution of non equilibrium quasiparticle and phonon distributions in superconducting films'', Swiss Workshop on Superconductivity, Les Diablerets, CH, October 1996.
R. M. Füchslin, P. F. Meier, “Level-Crossing Resonance Spectra for Bond-Centered Muonium in Silicon'', Meeting of the British Radio Spectroscopy Group at King's College, London 1995. TalksR. M. Füchslin, “Reactive cellular compartment dynamics by mesocscopic simulation methods: Application of mprDPD and mprDCD”, workshop “Modeling in Systems Biology”, 17, 10. 2007, Heidelberg, Germany. R. M. Füchslin, “Evolutionary Algorithms for Self-Assembling Systems: Simulations as a Tool for Optimizing Optimization”, ODES workshop, 15. 7. 2007, Venice. R. M. Füchslin, “Evolving Self-Assembling Digital Circuitry: Towards Realistic Models”, Int. Conf. on Morphological Computation, March 26-28 (2007), Venice, Italy. Peter Eggenberger Hotz and R. M. Füchslin (Joint talk), “Simulation of Assembling Vesicular Structures”, ECLT workshop on simulation and self-assembly, March 20-21 (2007), Venice, Italy. R. M. Füchslin, “Dynamic compartmentalization using mprDPD”, talk at the ECLT workshop on mesoscopic simulation, October 2-14, 2006. Venice Italy. R. M. Füchslin, “Studying dynamic compartmentalization using mprDPD”, talk at ECCS 05 November 13-18, 2005. Paris, France, R. M. Füchslin and T. Maeke, “Evolution and Genetic Self-Assembly”, talk at “Evolution, Information and Computation: From Living to Non-Living Matter”, Workshop, European Center for Living Technology, Venice, Italy, 23rd - 26th May 2005 R. M. Füchslin, “Evolving Logical Circuits via Genetic Self-Assembly”, talk at “Evolution: from Biology to Statistical Modeling”, An International School of Mathematics "G. Stampacchia" 41th Workshop at "Ettore Majorana" Foundation and Centre for Scientific Culture, July 3-9 2004, Erice, Italy. R. M. Füchslin and T. Maeke, “Dissipative Particle Dynamcis -Towards Chemistry in DPD”, talk at PACE-ECLT Integrated Twin Workshop. Multiscale Molecular Simulations and Stochastic Feedback. November 22 - December 5, 2004. ECLT, Venice, Italy. R. M. Füchslin, “Kommunikationsfehler, die gemacht zu haben ein Wissenschaftler eventuell in Betracht ziehen würde”, FhG-Seminar für angehende Wissenschaftsjournalisten, 5. Dezember 2003, Sankt Augustin. R. M. Füchslin,“Influence of Complex Formantion on Replicase Stabilization”, 38th winterseminar of Manfred Eigen, January 2003 Klosters. R. M. Füchslin, „Bauingenieurswesen im Informationsraum“, FhG-Seminar für angehende Wissenschaftsjournalisten, 13. Oktober, Sankt Augustin. R. M. Füchslin, “Origin of genetic information from minority control in replicating system with mutually catalytic molecules - About a theoretical model of K. Kaneko''. FhG-seminar Jun 2002. R. M. Füchslin, “Evolution auf dem Computer'', FhG Girls Day 2002. R. M. Füchslin, “The Influence of Space on Evolutionary Dynamics'', Physic Colloquium Univ. Zürich, Dec 2001. R. M. Füchslin, “Quantum Computation'', GMD-seminar, Nov. 2000. R. M. Füchslin, “Molecular State Machines'', GMD-seminar, Jun. 2000. R. M. Füchslin, “Analytical Calculations in muSR'' 31. winter school on nuclear and particle physics, Repino, St. Petersburg, Russia, February 1997. R. M. Füchslin, “Computersimulation in der Biologie'', Talk in ``Nachdiplomkurs'' at the Univ. Zürich, 1997. R. M. Füchslin, “Anyons, Fractional Statistics and Two Dimensional Physics'', CAP-seminar, Univ. Zürich, 1996. R. M. Füchslin, “Superfluid Helium'', Physics Colloquium, Zürich, November 1996. R. M. Füchslin, “Time evolution of quasiparticle and phonon distributions in superconducting films'', 6th International Conference on Low Temperature Detectors, Beatenberg, Switzerland, August 28 - Septmber 2, 1995. Patents„Bioelektrische Vielkanalsteuerung von Molekülen / Biomolekülen mittels einer Niedrigvolt-Digitalsteuerung'', PCT/EP03/05417.
„Multiplexverfahren zur massiv-parallen Steuerung von Molekülen/Biomolekülen in Mikrostrukturen'', PCT/EP03/05418, PAT042962US.
Schweizerische Patentanmeldung Nr. 857/02 vom 22. Mai 2002, Titel: Medizinische Pumpvorrichtung
Schweizerische Patentanmeldung Nr. 2110/01 vom 16. Nov. 2001, Titel: Medizinische Pumpvorrichtung, according international patent PCT/IB 02/ 04711.
Verfahren und Vorrichtung zur Ueberwachung einer Kathetereinrichtung'', Eidgenössisches Patent Nr. 2814/97.
I am noted as a co-inventor in all these patents, in case of patent Nr. 2110/01 resp. PCT/IB 02/ 04711 in leading position. Some of these patents are not anymore upheld by third parties that bought them.
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